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The intestinal mucosal barrier (IMB) is among the essential boundaries to forestall dangerous substances and pathogens from coming into the physique atmosphere and to take care of intestinal homeostasis. The dysfunction of the IMB is related to intestinal illnesses and problems. Nanomaterials have been broadly utilized in medication and as drug carriers as a result of their giant particular floor space, robust adsorbability, and good biocompatibility. On this assessment, we comprehensively focus on the affect of typical nanomaterials on the IMB and summarize the therapy of intestinal illnesses through the use of nanomaterials. The consequences of nanomaterials on the IMB are primarily influenced by components such because the dosage, measurement, morphology, and floor purposeful teams of nanomaterials. There may be big potential and a broad prospect for the appliance of nanomaterials in regulating the IMB for attaining an optimum therapeutic impact for antibiotics, oral vaccines, drug carriers, and so forth.
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